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The rapid testing capabilities of electrochemical biosensors is among one of their greatest advantages. Results are obtained within minutes, rather than hours or days with other conventional techniques. Waiting for days for results can lead to further viral communication in the community, or even death in the absence of proper care. Earlier response is vital to stopping the spread of disease and the key to saving lives.
With significant global viral outbreaks becoming the norm rather than generational outliers, it is imperative that fast, sensitive, and cost-effective testing is available to the masses. It is only by a concerted effort of testing and tracing that viral outbreaks can be effectively controlled before becoming global pandemics.
Screen-printed electrodes (SPEs) allow rapid, widespread testing of populations for infectious disease, without the need of skilled personnel or burdensome equipment in the field. The possibility of point-of-care (POC) testing with SPEs has been exhibited in several recent studies. Metrohm DropSens, a manufacturer of SPEs as well as their compact measuring devices, is the right partner for virology research projects—big and small. With a high production capability, combined with a valid ISO 13485 certification «Manufacturing of sensors for medical devices», this means testing procedures developed on DropSens SPEs can be reliably scaled up for larger operations, with easier approval by the Food and Drug Administration (FDA). As the leading brand in the market for this printing technology, Metrohm DropSens can design custom-made SPEs and offers the expertise and exceptional customer support needed for complicated projects at scale.
White Paper: Virus detection: Fast, sensitive, and cost-effective with electrochemical testing
Viral outbreaks and human health
Unlike the majority of bacteria, most viruses cause disease. Viruses, however, cannot survive without hosts, and therefore spread easily especially in densely populated areas. While bacterial infections can be fought with a range of antibiotics, viruses require specific vaccines which can be extremely difficult to manufacture.
Several viral outbreaks have caught global attention and attracted calls for faster, more accessible testing, including Ebola, avian influenza virus (H5N1, H1N1, and others), hepatitis, malaria, noroviruses, dengue, adenovirus, SARS (severe acute respiratory syndrome, HIV (human immunodeficiency virus), and even HPV (human papillomavirus). While some are capable of killing their human hosts in a relatively short timespan, others can linger for decades.
One commonality between these diseases is that they have all been successfully tested with disposable, custom-made SPEs from Metrohm DropSens.
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The global pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), more commonly known as «COVID-19», has monopolized the headlines for several months. Each country’s response has varied: from the tactics of encouraging normalcy to attempt quicker herd immunity, to extremely strict quarantine measures, especially for the elderly, and the closure of borders and non-essential industries. However, the most effective way to trace and contain the spread of viruses is through comprehensive testing.
General viral testing methods and their drawbacks
The importance of testing for the presence of harmful viruses in the population cannot be overstated. In order to stop the spread of especially communicable diseases, testing must be accurate, reliable, timely, affordable, and of course widely available.
Viral testing can be accomplished via several different methods, including virus isolation cultures, enzyme-linked immunosorbent assay (ELISA), and other molecular methods like polymerase chain reaction (PCR) and reverse transcription polymerase chain reaction (RT-PCR).
High costs limit the affordability and overall availability of such tests to the general population, especially for poorer communities. Complicated analytical procedures require trained professionals, specialty chemicals, and bulky instruments, which may not be available in all areas. On top of this, the waiting time between test and result is prohibitive – sometimes taking several days, which could mean the difference between life or death.
Benefits of electrochemical testing
Recently, initiatives for diagnostic testing methods have been launched by agencies such as the WHO to create faster, more accurate, affordable tests—especially in low-resource areas. For these reasons, electrochemical testing methods have been developed on disposable screen-printed electrodes, exhibiting major promise for fast, affordable, precise testing directly at the point of care.
Click the topics below to learn more about the benefits of SPEs in this field.
Specific electrochemical detection techniques (e.g., voltammetric or amperometric analysis) already allow for the detection of low analyte concentrations. The high adsorption capabilities of carbon-based working electrodes where certain recognition elements are attached play a key role in the improvement of sensitivity. To further decrease the detection limit, signal amplification by chemical or electrochemical catalytic reactions are commonly used.
The compact size of the measuring device, not to mention the SPEs themselves, equates to complete portability for testing on the go. Simply add a small volume of sample to the electrode, insert it into the measuring device, and receive results about viral exposure in minutes.
The low cost per test is a great advantage of using screen-printed electrodes for virology studies. Each SPE is meant to be disposable after a single use, ensuring a fresh substrate for every sample. The affordability and portability of SPEs and their measuring devices makes this technique much more attractive for economically depressed areas or regions without an abundance of specialized testing facilities.
Metrohm DropSens is certified by ISO 13485 «Manufacturing of sensors for medical devices». This certification permits a simpler pathway to regulatory approval (such as by the FDA) and leads to quicker commercialization of validated tests developed on these products in the medical field.
Selection of screen-printed electrodes manufactured by Metrohm DropSens.
Metrohm DropSens has the technology to develop screen-printed electrodes based on the individual needs of the customer. The configuration and dimensions of the electrodes are adapted to their specific requirements.
Find out more in our blog post «Developing the electrochemical sensors of your dreams».
The large-scale manufacturing capabilities at Metrohm DropSens guarantee a trusted, reliable source for the mass production of SPEs suitable for viral testing. With decades of electrochemical expertise, a worldwide distribution network, and top class after-sales support, the widespread commercialization of tests developed on these products is no problem.
Summary
Point-of-care testing with screen-printed electrodes allows rapid, widespread testing of populations for viral outbreaks at a low cost and without the need for skilled analysts or complicated measuring equipment. Fast results mean quicker reaction times – for swift treatment, but also for tracing the spread of contagion and developing a concerted response before the situation gets more out of control.
Portability and the simplicity of use allows rapid testing with screen-printed electrodes in all situations, not only off-site in specialized laboratories with a skilled staff. Since SPEs are customizable, they can be modified and manufactured to suit the needs of all types of research groups.
Metrohm DropSens SPEs are ISO 13485 certified, meaning that testing procedures developed on these products require shorter times to receive FDA approval and commercialization. The bulk manufacturing capability of Metrohm DropSens guarantees a stable commercial source for custom-made SPEs and their measuring devices at any order size—big or small.
Metrohm DropSens: a complete solution provider
As a market leader in manufacturing reliable screen-printed electrodes as well as their measuring devices, Metrohm DropSens is the ideal partner for virology studies based on electrochemical testing, as well as for other research involving SPEs.
For more information, visit the Metrohm DropSens website below to have an overview of our products, capabilities, and additional peer-reviewed scientific literature featuring these electrodes and measuring devices.
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