Ion chromatography applications
Ion chromatography (IC), or ion exchange chromatography is a powerful analytical technique used to separate and quantify ions in a sample. By leveraging the principles of ion exchange and conductivity detection, IC delivers precise and reliable results across various applications. Our application experts have compiled numerous documents for various industries, including environmental, food and beverage, and pharmaceuticals.
Use the filters to search for IC applications by analyte/parameter, sample matrix, norm, or industry.
- AN-S-404Water quality testing with EPA 300.1
The Metrosep A Supp 21 column and 948 Continuous IC Module, CEP enable efficient, automated single-run analysis of major anions and disinfection byproducts in water.
- AB-380Installation Instruction for ProfIC Vario 7 Cation
This document describes the recommended equipment and installation of a Professional IC Vario system with combined MISP techniques of Inline Dilution and Inline Dialysis.
- AB-379Installation Instruction for ProfIC Vario 7 Anion
This document describes the recommended equipment and installation of a Professional IC Vario system with combined MISP techniques of Inline Dilution and Inline Dialysis.
- AN-C-198Calcium acetate assay in calcium acetate capsules
The assay of calcium acetate, often used as a phosphate binder for dialysis patients, can be performed with ion chromatography (IC) as per USP <621> and <1225>.
- AN-C-197Potassium assay in potassium citrate and citric acid oral solution
Potassium citrate and citric acid oral solutions act as systemic alkalizers. Potassium assays, validated per USP <621> and <1225>, use IC with L76 cation-exchange columns.
- AN-CIC-035Halogens and sulfur in solid samples according to EN 17813
Organic halides must be monitored in the environment. Combustion ion chromatography (CIC) is used for accurate halogen analysis in solids following EN 17813:2023.
- AN-C-195Cation quantification with increased performance using microbore IC
Microbore ion chromatography offers better sensitivity, shorter retention times, and consumes less eluent, increasing sample throughput and reducing running costs.
- AN-C-196Purity quantification of tris(hydroxymethyl)aminomethane (TRIS) with IC
Tris(hydroxymethyl)aminomethane (TRIS) is often used in life science applications and its purity must be monitored. This analysis is possible with ion chromatography.
- WP-092USP monograph modernization initiative leading to modern ion chromatography-based methods
The USP and FDA started to modernize several monographs and General Chapters. In many cases, IC-focused methods have replaced older, wet chemistry procedures. Learn more about the USP modernization initiative and the advantages of ion chromatography in this white paper.
- AN-S-402Nitrite in hydroxypropyl methylcellulose
Nitrosamine formation can be avoided by controlling the nitrite concentration in pharmaceutical products and processes. To monitor nitrosamine formation, sensitive analytical methods such as ion chromatography for the determination of nitrite in pharmaceutical products and substances are essential.
