Dr. Christian Haider, Head of the Competence Center Titration at Metrohm International Headquarters, presents best practice guidelines how you can replace your manual titations by automatic procedures using a photometric or potentiometric sensor in combination with a modern titrator.
Advantages of automatic titration
Automatic titration has many advantages over manual titration, including:
- Easier preparation and simple filling of the buret: The automatic buret safely controls the delivery of titrant to a precise level
- More reliable and reproducible endpoint evaluation: The electrode detects the titration endpoint removing subjectivity of color changes
- Complete documentation according to GxP: Results calculations are automatically performed and saved after the titration
- Increased safety: Safer handling of chemicals
Learn more in related blog articles:
How to avoid titration errors in your lab
USP recommendations: Overcoming manual titration
The United States Pharmacopeia (USP) has published recommendations on replacing manual titration with automated titration for a wide range of pharmaceutical assays. This project was initiated by USP in collaboration with Metrohm to respond to current requirements regarding data integrity (ALCOA) and compliance (FDA 21 CFR part 11).
We have compiled more information in white papers to help you follow the recommendations by USP and to validate titration methods.