Zinc is an essential trace element which is used in different pharmaceuticals and supplements [1]. In the form of zinc oxide, zinc is an integral part of skin care creams, pastes, and supplements [2,3]. In order to meet the stringent quality standards for pharmaceutical products, manufacturers and laboratories must employ validated methods as from the United States Pharmacopeia and National Formulary (USP-NF). In the course of their modernization activities, USP-NF also updated the zinc monograph and replaced the existing identification procedure with titration by ion chromatographic analyses. Ion chromatography (IC) qualified as a methodical approach for the zinc assay in General Chapter <591>, Zinc Determination [4]. The analysis involves separation of zinc using, e.g., L91 column material (Metrosep A Supp 10) followed by post-column reaction using 4-(2-pyridylazo)resorcinol (PAR) and subsequent detection at 530 nm. IC was validated according to USP procedures as a highly specific and accurate method to ensure product safety and quality.